NAME THE GENETIC DISEASE IN WHICH MUTATIONS OF TWO (2) SEPARATE GENES (LAMC2 AND LAMA3) CAUSE AN IDENTICAL PHENOTYPE IN THE HORSE.
1. Name the function of a Merkel cell. (1 mark)2. Name the genetic disease in which mutations of two (2) separate genes (LAMC2 andLAMA3) cause an identical phenotype in the horse. (1 mark)3. Name a major component of the outer plaque of the hemidesmosome. (1 mark)4. Name an autoimmune disease associated with abnormalities of the outer plaque of thehemidesmosome in dogs. (1 mark)5. Name the structural molecule associated with recessive dystrophic epidermolysisbullosa of Rotes Hohenvieh calves. (1 mark)6. Name the gene associated with hereditary cutaneous mucinosis of the ChineseShar pei. (1 mark)7. State the mechanism by which copper deficiency leads to abnormalities inpigmentation in cattle. (1 mark)8. Name the precursor of adrenocorticotropin hormone (ACTH) and melanocytestimulating hormone (MSH). (1 mark)9. Name the equine skin disease in which the cytokine thymic stromal lymphopoietin(TSLP) has been shown to be over expressed. (1 mark)Continued over pageVeterinary Dermatology Paper 1 Page 3 of 7© 2015 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 20810. Name a molecular target of autoantibodies in human autoimmune urticaria. (1 mark)11. Name a primary constituent of the cell wall of Pythium insidiosum. (1 mark)12. Name the protein encoded by the ABCB1 (MDR1) gene. (1 mark)13. State the primary function of Class 2 major histocompatibility complex (MHC)molecules. (1 mark)14. Name the major anatomical location of collagen type VII. (1 mark)15. Name a resident cutaneous cell that contains abundant vimentin. (1 mark)16. Name the two (2) resident cutaneous cells dependent on stem cell factor for theirembryologic development. (1 mark)17. Name a major function of interleukin-5. (1 mark)18. Name the major structural component of the layer of the dermo-epidermal junctionknown as the lamina densa. (1 mark)19. Name the group of calcium dependent enzymes critical for formation of the cornifiedenvelope. (1 mark)20. Name the disease caused by mutations in the genes coding for keratins 5 and 14.(1 mark)Continued over pageVeterinary Dermatology Paper 1 Page 4 of 7© 2015 The Australian and New Zealand College of Veterinary Scientists ABN 00 50 000894 20821. Name the antibody isotype that has a dimeric structure. (1 mark)22. Name the step in the cholesterol to cortisol pathway catalysed by 3betahydroxysteroid dehydrogenase. (1 mark)23. Name one (1) commonly used proliferation marker in cutaneous veterinary oncology.(1 mark)24. Name the Toll-like receptor that mediates the host response to gram positive bacteria.(1 mark)25. Name three (3) techniques that have been reported for the demonstration of IgEresponses to Malassezia pachydermatis in dogs. (1 mark)26. Name the receptor on the keratinocyte surface which has been demonstrated torecognise chitin in the exoskeleton of Demodex canis. (1 mark)27. Define the term ‘cutaneous microbiome’. (1 mark)28. Provide the term now used to describe hairless telogen. (1 mark)29. Name the two (2) classes of antimicrobial peptides that are synthesised byinflammatory cells and epithelial surfaces. (1 mark)
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